A Multicenter, 10-Year Experience With Hepatocellular Adenoma: Risk Factors and Disease Course
| Autor: | Trevor Silva, Andrew L DiFronzo, Michael Sung, Daniel W. Nelson, Victoria V O'Connor |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Adenoma medicine.medical_treatment Patient demographics Adenoma Liver Cell Disease course Young Adult Risk Factors Internal medicine medicine Humans Aged Aged 80 and over business.industry Liver Neoplasms Mean age General Medicine Middle Aged Hepatocellular adenoma medicine.disease Disease Progression Population study Female Disease characteristics Hepatectomy business Contraceptives Oral |
| Zdroj: | The American Surgeon. 88:2345-2350 |
| ISSN: | 1555-9823 0003-1348 |
| Popis: | Background Management of hepatocellular adenoma (HA) is marked by a paucity of recent studies. Long-term follow-up data from an equal access health care system may facilitate our understanding of the natural disease course of HA and identify modifiable risk factors. Methods A multi-institutional, retrospective review of patients with HA from 2008-2017 was performed. Patient demographics, disease characteristics, and clinical outcomes were analyzed. Results Of 124 patients identified, 94% were women with a mean age at diagnosis of 39.5 years (range 20-82). Median follow-up was 22.5 months (range 0-114) with thirty-four (27.4%) patients eventually undergoing hepatectomy. Mean BMI of the study population was 30.5 kg/m2 (range 16-72). Stratified by size, average BMI for adenomas ≥5 cm was 34 kg/m2 compared to 28 kg/m2 for those Discussion This decade-long review analyzing the impact of modifiable risk factors identifies a direct correlation between BMI and hepatocellular adenoma size. Rupture and malignant transformation are rare entities. Cessation of OC appears to be an effective strategy in the management of hepatic adenoma. Further investigations are warranted to determine if addressing modifiable risk factors such as BMI might induce further HA regression. |
| Databáze: | OpenAIRE |
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