Fibrin sealants in soft tissue surgery of the head and neck: A systematic review and meta-analysis of randomised controlled trials
| Autor: | Richard Shaw, Mandeep S. Bajwa, Catrin Tudur-Smith, Andrew Schache |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Fibrin Tissue Adhesive 030230 surgery 03 medical and health sciences Postoperative Complications 0302 clinical medicine medicine Humans Parotid Gland 030223 otorhinolaryngology Randomized Controlled Trials as Topic business.industry Thyroidectomy Neck dissection Surgical wound medicine.disease Surgery Clinical trial Dissection Otorhinolaryngology Meta-analysis Seroma Rhytidoplasty Drainage Neck Dissection business Rhytidectomy |
| Zdroj: | Clinical Otolaryngology |
| ISSN: | 1749-4478 |
| Popis: | Background Fibrin sealants (FS) are commercially available products used in surgical wounds as adjuncts to haemostasis and closure of dead space. The role of FS in soft-tissue head and neck surgery has not been established. Objectives To assess if FS improves wound related outcomes in patients undergoing soft-tissue surgery of the head and neck anatomical region that would commonly require a drain. Type Of Review Systematic review and meta-analysis of randomised controlled trials (RCTs). Search Strategy Medline (1946 – 2016), EMBASE (1974 – 2016), PubMed (2016), CENTRAL (2016), ClinicalTrials. gov (2016), WHO International Clinical Trials Registry and Platform (2016), Research Gate (2016). Evaluation Method Two independent reviewers screened and selected studies. Included studies were assessed for risk of bias and data extracted using a predetermined data collection form. Results Of the 421 studies that were screened 11 RCTs met the inclusion criteria. There were 2 RCTs on thyroidectomy, 3 on ‘surgery involving neck dissection’ (central or lateral), 5 on rhytidectomy and 1 on parotidectomy. There was a tendency for FS to reduce ‘mean total drainage volume’ (mean difference -26.86ml, 95%CI -43.41 to -10.31, I2=97%, p=0.001). Sub-group analysis of thyroidectomy (mean difference -36.36ml, 95%CI -72.82 to 0.10, I2=79%, p=0.05), ‘surgery involving neck dissection’ (mean difference -33.21ml, 95%CI -70.01 to 3.59, I2=94%, p=0.08) and rhytidectomy (mean difference -13.79ml, 95%CI -17.57 to -10.01, I2=0%, p |
| Databáze: | OpenAIRE |
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