EEG source analysis in obsessive–compulsive disorder

Autor: Martin Brunovský, Jan Prasko, Michal Raszka, Jana Kopřivová, Jiří Horáček, Cyril Höschl, Barbora Kohútová, Marco Congedo
Přispěvatelé: Third Faculty of Medicine, Charles University, Praha, Charles University [Prague] (CU), GIPSA - Vision and Brain Signal Processing (GIPSA-VIBS), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2011
Předmět:
Adult
Male
Obsessive-Compulsive Disorder
medicine.medical_specialty
Frontal cortex
medial frontal cortex
Electroencephalography
Audiology
behavioral disciplines and activities
Developmental psychology
03 medical and health sciences
0302 clinical medicine
Obsessive compulsive
Physiology (medical)
mental disorders
medicine
Humans
In patient
Eeg source localization
Obsessive-compulsive disorder (OCD)
medicine.diagnostic_test
[SCCO.NEUR]Cognitive science/Neuroscience
Brain
Signal Processing
Computer-Assisted
Medial frontal cortex
medicine.disease
Independent component analysis
Sensory Systems
standardized low-resolution electromagnetic tomography (sLORETA)
030227 psychiatry
Neurology
obsessive-compulsive disorder (OCD)
Female
Neurology (clinical)
independent component analysis (ICA)
Psychology
030217 neurology & neurosurgery
Zdroj: Clinical Neurophysiology
Clinical Neurophysiology, Elsevier, 2011, 122 (9), pp.1735-1743. ⟨10.1016/j.clinph.2011.01.051⟩
ISSN: 1388-2457
DOI: 10.1016/j.clinph.2011.01.051
Popis: International audience; OBJECTIVE: The goal of this study was to assess the activity of intracortical EEG sources in patients with OCD. METHODS: We compared resting state EEG from 50 OCD patients and 50 matched controls using standardized low-resolution electromagnetic tomography (sLORETA) and normative independent component analysis (NICA). Data were analyzed with 1 Hz frequency resolution. Group ICA was used to separate 7 independent components from the control group data. The resulting weights and norms served to derive the same components from the OCD group and to compare their power with controls. RESULTS: In OCD, sLORETA indicated low-frequency power excess (2 - 6 Hz) in the medial frontal cortex, whereas group ICA showed increased low-frequency power in a component reflecting the activity of subgenual anterior cingulate, adjacent limbic structures and to a lesser extent also of lateral frontal cortex. CONCLUSIONS: Both methods provided evidence for medial frontal hyperactivation in OCD. SIGNIFICANCE: Our study is the first to use normative ICA in a clinical sample and indicates its potential utility as a diagnostic tool. The findings provide consistent results based on EEG source localization in OCD and are of practical interest for therapeutic interventions.
Databáze: OpenAIRE
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