Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?
| Autor: | Bahram Pourghassem Gargari, Sara Ebrahimi, Fereshteh Aliasghari, Foad Asjodi, Bahareh Imani, Masoumeh Jabbari, Azimeh Izadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
lipid profiles medicine.medical_treatment NAFLS Adipokine 030209 endocrinology & metabolism Inflammation inflamacija Disease 030204 cardiovascular system & hematology lcsh:Biochemistry 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine insulin resistance NAFLD medicine lcsh:QD415-436 adipokines Original Paper medicine.diagnostic_test business.industry Insulin Fatty liver lipidni profil adipokini nutritional and metabolic diseases medicine.disease digestive system diseases Blood pressure Endocrinology insulinska rezistencija inflammation Abdominal ultrasonography medicine.symptom business |
| Zdroj: | Journal of Medical Biochemistry Journal of Medical Biochemistry, Vol 37, Iss 4, Pp 470-475 (2018) |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure.This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omentin-1, vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed.Partial correlations controlling for age and sex showed significant positive correlation between vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP. It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between omentin levels and systolic blood pressure (SBP).This study shows that vaspin and omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD.Oboljenje ne-alkoholna masna jetra (NAFLD) je posledica promene na jetri usled insulinske rezistencije je najčešći uzrok hroničnog oboljenja jetre. Ovaj rad ima za cilj ispitivanje uloge vaspina i ometina-1 u NAFLD-patologiji, inflamaciji i povećanom krvnom pritisku.Ispitivanja su izvedena na 83 NAFLD pacijenta u Jahrom-u, Iran. Mereni su nivoi ometina-1, vaspina, hs-CRP i IL-6. Ispitivani su antropometrijski parametri, profil lipida, jetreni enzimi i abdominalna ultrasonografija.Delimičnom korelacijom između pola i starosti ukazala su na pozitivnu korelaciju između vaspina i nivoa glukoze u krvi (FBS), insulina, HOMA-IR i hs-CRP. Nađeno je da je ometin u negativnoj korelaciji sa nivoima glukoze. Međutim, marginalno značajna veza je nađena između nivoa ometina i sistolnog krvnog pritiska (SBP).Rezultati su pokazali da vaspin i ometion-1 su praćeni inflamacijom, insulinskom rezistencijom u nivoima glukoze u serumu kod pacijenata sa NAFLD. |
| Databáze: | OpenAIRE |
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