Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial
Autor: | Christos S. Mantzoros, Aoife M. Brennan, Frank B. Hu, Qi Sun, Nicole M. Wedick, Rob M. van Dam |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty 030309 nutrition & dietetics alpha-2-HS-Glycoprotein Physiology Medicine (miscellaneous) 030209 endocrinology & metabolism lcsh:TX341-641 Type 2 diabetes Overweight Coffee Beverages 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Risk Factors Internal medicine Diabetes mellitus Caffeine medicine Humans lcsh:RC620-627 2. Zero hunger 0303 health sciences Nutrition and Dietetics Adiponectin business.industry Interleukin-6 Research Middle Aged medicine.disease 3. Good health lcsh:Nutritional diseases. Deficiency diseases Endocrinology chemistry Diabetes Mellitus Type 2 Female Liver function medicine.symptom Insulin Resistance business Body mass index lcsh:Nutrition. Foods and food supply |
Zdroj: | Nutrition Journal, Vol 10, Iss 1, p 93 (2011) Nutrition Journal |
ISSN: | 1475-2891 |
Popis: | Background Coffee consumption has been associated with a lower risk of type 2 diabetes in prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this study was to evaluate the effects of regular and decaffeinated coffee on biological risk factors for type 2 diabetes. Methods Randomized parallel-arm intervention conducted in 45 healthy overweight volunteers who were nonsmokers and regular coffee consumers. Participants were assigned to consumption of 5 cups (177 mL each) per day of instant caffeinated coffee, decaffeinated coffee, or no coffee (i.e., water) for 8 weeks. Results Average age was 40 years and body mass index was 29.5 kg/m2. Compared with consuming no coffee, consumption of caffeinated coffee increased adiponectin (difference in change from baseline 1.4 μg/mL; 95% CI: 0.2, 2.7) and interleukin-6 (difference: 60%; 95% CI: 8, 138) concentrations and consumption of decaffeinated coffee decreased fetuin-A concentrations (difference: -20%; 95% CI: -35, -1). For measures of glucose tolerance, insulin sensitivity, and insulin secretion, no significant differences were found between treatment groups. Conclusions Although no changes in glycemia and/or insulin sensitivity were observed after 8 weeks of coffee consumption, improvements in adipocyte and liver function as indicated by changes in adiponectin and fetuin-A concentrations may contribute to beneficial metabolic effects of long-term coffee consumption. Trial Registration clinicaltrials.gov NCT00305097 |
Databáze: | OpenAIRE |
Externí odkaz: |