Association of FcγRIIA‐R/H131 polymorphism and systemic lupus erythematosus lupus nephritis risk: A meta‐analysis

Autor:	Yue-Rong Ma, Hui-Ting Wei, Jun‐Ju Zou, Yuan Xu
Rok vydání:	2020
Předmět:	medicine.medical_specialty Population Lupus nephritis Risk Assessment Gastroenterology 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Polymorphism (computer science) Internal medicine Genotype medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease 030212 general & internal medicine Allele education Genetic Association Studies 030203 arthritis & rheumatology education.field_of_study Polymorphism Genetic Systemic lupus erythematosus business.industry Receptors IgG Odds ratio medicine.disease Lupus Nephritis Phenotype business Nephritis
Zdroj:	International Journal of Rheumatic Diseases. 23:853-867
ISSN:	1756-185X 1756-1841
DOI:	10.1111/1756-185x.13815
Popis:	AIM Previous studies have discussed association of FcγRIIA-R/H131 polymorphism and systemic lupus erythematosus (SLE), lupus nephritis (LN) risk. However, conclusions were inconsistent. METHODS A meta-analysis was performed in this study with allelic contrast (allele R vs H), additive model (genotype RR vs HH), recessive model (genotype RR vs RH + HH), and dominant model (genotype RR + RH vs HH). RESULTS A total of 33 studies discussed the correlation between FcγRIIA-R/H131 polymorphism and SLE, involving 5652 SLE patients and 6322 controls. Allele R was significantly related to SLE in the overall population (odds ratio [OR] = 1.238, P
Databáze:	OpenAIRE
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