Review of the Geant4-DNA Simulation Toolkit for Radiobiological Applications at the Cellular and DNA Level
| Autor: | Ioanna Kyriakou, Dousatsu Sakata, Hoang Ngoc Tran, Yann Perrot, Wook-Geun Shin, Nathanael Lampe, Sara Zein, Marie Claude Bordage, Susanna Guatelli, Carmen Villagrasa, Dimitris Emfietzoglou, Sébastien Incerti |
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| Přispěvatelé: | Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Cancer Research
Geant4-DNA IRT Neoplasms. Tumors. Oncology. Including cancer and carcinogens DNA repair Review radiobiological modelling step by step mechanistic modeling 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Oncology 030220 oncology & carcinogenesis [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] DNA damage Monte Carlo track-structure RC254-282 |
| Zdroj: | Cancers Cancers, MDPI, 2022, 14 (1), pp.35. ⟨10.3390/cancers14010035⟩ Cancers, Vol 14, Iss 35, p 35 (2022) |
| ISSN: | 2072-6694 |
| Popis: | Simple Summary A brief description of the methodologies to simulate ionizing radiation transport in biologically relevant matter is presented. Emphasis is given to the physical, chemical, and biological models of Geant4-DNA that enable mechanistic radiobiological modeling at the cellular and DNA level, important to improve the efficacy of existing and novel radiotherapeutic modalities for the treatment of cancer. Abstract The Geant4-DNA low energy extension of the Geant4 Monte Carlo (MC) toolkit is a continuously evolving MC simulation code permitting mechanistic studies of cellular radiobiological effects. Geant4-DNA considers the physical, chemical, and biological stages of the action of ionizing radiation (in the form of x- and γ-ray photons, electrons and β±-rays, hadrons, α-particles, and a set of heavier ions) in living cells towards a variety of applications ranging from predicting radiotherapy outcomes to radiation protection both on earth and in space. In this work, we provide a brief, yet concise, overview of the progress that has been achieved so far concerning the different physical, physicochemical, chemical, and biological models implemented into Geant4-DNA, highlighting the latest developments. Specifically, the “dnadamage1” and “molecularDNA” applications which enable, for the first time within an open-source platform, quantitative predictions of early DNA damage in terms of single-strand-breaks (SSBs), double-strand-breaks (DSBs), and more complex clustered lesions for different DNA structures ranging from the nucleotide level to the entire genome. These developments are critically presented and discussed along with key benchmarking results. The Geant4-DNA toolkit, through its different set of models and functionalities, offers unique capabilities for elucidating the problem of radiation quality or the relative biological effectiveness (RBE) of different ionizing radiations which underlines nearly the whole spectrum of radiotherapeutic modalities, from external high-energy hadron beams to internal low-energy gamma and beta emitters that are used in brachytherapy sources and radiopharmaceuticals, respectively. |
| Databáze: | OpenAIRE |
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