Does Dietary α-Linolenic Acid Promote Liver Metastases in Pancreatic Carcinoma Initiated by BOP in Syrian Hamster?
| Autor: | C.A. Jacobi, F.A. Wenger, J M Müller, J. Zieren, M. Kilian, H.U. Zieren |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Nitrosamines Pancreatic disease Linolenic acid Medicine (miscellaneous) Hamster Biology medicine.disease_cause Metastasis Dietary Fats Unsaturated Cricetinae Internal medicine medicine Animals Nutrition and Dietetics Mesocricetus Incidence Liver Neoplasms alpha-Linolenic Acid Biological activity medicine.disease biology.organism_classification Pancreatic Neoplasms medicine.anatomical_structure Endocrinology Carcinogens Pancreas Carcinogenesis Mutagens |
| Zdroj: | Annals of Nutrition and Metabolism. 43:121-126 |
| ISSN: | 1421-9697 0250-6807 |
| Popis: | Background: α-Linolenic acid (ALA) has been shown to have a promoting effect on pancreatic carcinogenesis. The purpose of this study was to evaluate the influence of ALA on liver metastases in a model of BOP-induced pancreatic ductular carcinoma in the Syrian golden hamster. Methods: While the control group (group V) received a standard diet low in fat (soya oil, 3 w/v) without ALA, groups I–IV were fed a diet high in fat (soya oil 25 w/v) with increasing percentages of ALA (2.5, 5, 7.5 and 10%) for 16 weeks. Results: No significant differences in mean body weight and pancreas weight were found between the groups. But significant differences (p = 0.0001) were observed in the mean weight of the resected liver. Treatment with BOP alone resulted in the induction of well-differentiated ductal pancreatic adenocarcinoma in 91%, while all groups treated with different amounts of ALA had induction of 100%. The incidence of liver metastases differed significantly between the groups. The incidence of liver metastases in group I (2.5% ALA) was 18%, in group II (5% ALA) 27%, in group III (7.5% ALA) 50%, and in group IV (10% ALA) 91%. Moreover, the diameter of liver metastases increased significantly according to ALA supplementation (p = 0.001). Conclusion: The results indicate that dietary ALA increases liver metastases in BOP-initiated pancreatic cancer. |
| Databáze: | OpenAIRE |
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