SARS-CoV-2, Cardiovascular Diseases, and Noncoding RNAs: A Connected Triad

Autor: Christian Weber, Fabio Virgili, Lucia Natarelli
Rok vydání: 2021
Předmět:
RNA
Untranslated
MICRORNAS
ACE2
Review
Bioinformatics
Viral infection
Biology (General)
Spectroscopy
Regulation of gene expression
Vaccines
Synthetic
Vaccines
GENOME SEQUENCE
Coronavirus/antagonists & inhibitors
General Medicine
Non-coding RNA
COVID-19/genetics
Spike Glycoprotein
Computer Science Applications
Angiotensin-Converting Enzyme 2/genetics
Chemistry
Spike Glycoprotein
Coronavirus
ENTRY
RNA Interference
Synthetic/administration & dosage
Angiotensin-Converting Enzyme 2
SARS-CORONAVIRUS
EXPRESSION
Coronavirus disease 2019 (COVID-19)
QH301-705.5
Adverse outcomes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
noncoding RNA
Catalysis
CLINICAL-TRIAL
Proinflammatory cytokine
Inorganic Chemistry
Untranslated/metabolism
SARS-CoV-2/genetics
Cardiovascular Diseases/genetics
medicine
Humans
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
ANGIOTENSIN-CONVERTING ENZYME-2
SARS-CoV-2
business.industry
Organic Chemistry
COVID-19
C VIRUS-RNA
medicine.disease
Comorbidity
cardiovascular diseases
SPIKE PROTEIN
RNA
business
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 12243, p 12243 (2021)
International Journal of Molecular Sciences
ISSN: 1422-0067
DOI: 10.3390/ijms222212243
Popis: Coronavirus Disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is characterized by important respiratory impairments frequently associated with severe cardiovascular damages. Moreover, patients with pre-existing comorbidity for cardiovascular diseases (CVD) often present a dramatic increase in inflammatory cytokines release, which increases the severity and adverse outcomes of the infection and, finally, mortality risk. Despite this evident association at the clinical level, the mechanisms linking CVD and COVID-19 are still blurry and unresolved. Noncoding RNAs (ncRNAs) are functional RNA molecules transcribed from DNA but usually not translated into proteins. They play an important role in the regulation of gene expression, either in relatively stable conditions or as a response to different stimuli, including viral infection, and are therefore considered a possible important target in the design of specific drugs. In this review, we introduce known associations and interactions between COVID-19 and CVD, discussing the role of ncRNAs within SARS-CoV-2 infection from the perspective of the development of efficient pharmacological tools to treat COVID-19 patients and taking into account the equally dramatic associated consequences, such as those affecting the cardiovascular system.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje