17β-Hydroxyestra-4,9,11-trien-3-one (Trenbolone) preserves bone mineral density in skeletally mature orchiectomized rats without prostate enlargement
| Autor: | Sally E. Johnson, Sean C. McCoy, Joshua F. Yarrow, Christine F. Conover, Thomas J. Wronski, Bryan P. Conrad, Jennifer E. Pingel, Fan Ye, Mark D. Tillman, Stephen E. Borst, Hordur G. Kristinsson, Paul A. Borsa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Histology Physiology medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Prostatic Hyperplasia Kidney Article Hemoglobins Anabolic Agents Bone Density Prostate Internal medicine Androgen deficiency medicine Animals Femur Orchiectomy Testosterone Femoral neck Bone mineral business.industry Body Weight Organ Size medicine.disease Androgen Rats Inbred F344 Biomechanical Phenomena Rats Endocrinology medicine.anatomical_structure Androgens Trenbolone Acetate business Biomarkers Anabolic steroid |
| Zdroj: | Bone |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2012.07.008 |
| Popis: | Testosterone enanthate (TE) administration attenuates bone loss in orchiectomized (ORX) rats. However, testosterone administration may increase risk for prostate/lower urinary tract related adverse events and polycythemia in humans. Trenbolone enanthate (TREN) is a synthetic testosterone analogue that preserves bone mineral density (BMD) and results in less prostate enlargement than testosterone in young ORX rodents. The purpose of this experiment was to determine if intramuscular TREN administration attenuates bone loss and maintains bone strength, without increasing prostate mass or hemoglobin concentrations in skeletally mature ORX rodents. Forty, 10 month old male F344/Brown Norway rats were randomized into SHAM, ORX, ORX+TE (7.0 mg/week), and ORX+TREN (1.0 mg/week) groups. Following surgery, animals recovered for 1 week and then received weekly: vehicle, TE, or TREN intramuscularly for 5 weeks. ORX reduced total and trabecular (t) BMD at the distal femoral metaphysis compared with SHAMs, while both TREN and TE completely prevented these reductions. TREN treatment also increased femoral neck strength by 28% compared with ORX animals (p |
| Databáze: | OpenAIRE |
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