Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)
| Autor: | V.M. Steffen, Jose Angelo Silveira Zuanazzi, Carolina dos Santos Passos, Fabiane M. Farias, A. T. Henriques, Marcelo Dutra Arbo |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Nervous system Serotonin Dopamine medicine.medical_treatment Intraperitoneal injection Central nervous system Pharmaceutical Science Rubiaceae Striatum Pharmacology Drug Discovery medicine Animals Psychotria Glycosides Rats Wistar Phenylacetates Neurotransmitter Agents biology Plant Extracts Homovanillic Acid biology.organism_classification Corpus Striatum Rats Plant Leaves Monoamine neurotransmitter medicine.anatomical_structure Complementary and alternative medicine Biochemistry 3 4-Dihydroxyphenylacetic Acid Molecular Medicine Injections Intraperitoneal Carbolines |
| Zdroj: | Phytomedicine. 17:289-291 |
| ISSN: | 0944-7113 |
| Popis: | Strictosidinic acid 10mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of Psychotria compounds. |
| Databáze: | OpenAIRE |
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