Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging in frontotemporal lobar degeneration
| Autor: | Jorge Campos, María Julieta Russo, Pablo Bagnati, Gabriela Cohen, Marcos Fernandez Suarez, Griselda Russo, David S. Knopman, Ricardo F. Allegri, Patricio Chrem, Alejandra Amengual, Daniela Buyatti |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Clinical Dementia Rating Neuropsychological Tests Severity of Illness Index Primary progressive aphasia Memory Rating scale mental disorders medicine Humans Dementia Psychiatry Aged Language Aged 80 and over Neuropsychology Frontotemporal lobar degeneration Middle Aged Translating medicine.disease Cross-Sectional Studies ROC Curve Neurology Disease Progression Female Neurology (clinical) Frontotemporal Lobar Degeneration Alzheimer's disease Psychology Personality Clinical psychology Frontotemporal dementia |
| Zdroj: | Journal of the Neurological Sciences. 344:63-68 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/j.jns.2014.06.024 |
| Popis: | Introduction The Clinical Dementia Rating Scale (CDR) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, in Alzheimer's disease (AD). A new version of the scale was developed by adding two extra domains that focused on the core aspects of frontotemporal dementia symptomatology, Language and Behavior/Comportment/Personality. Objectives In this study, we adapted and validated the modified CDR scale in our setting and language (Rioplatense-Spanish). Materials and methods 46 patients with probable AD, 27 behavioral variant of Frontotemporal Dementia (bvFTD), 18 Primary Progressive Aphasia (PPA) and 40 healthy participants were included. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. Results Using ROC curves, the domain language and behavior were superior to the memory domain in accuracy for detecting PPA and bvFTD, respectively, but both of them had equivalent diagnostic accuracies for probable AD. Logistic regression analyses showed that either the LANG or BEHAV domains significantly improved the discrimination between probable AD, bvFTD and PPA. Conclusions The Spanish version of the modified CDR adds value for the characterization of the non-amnestic symptoms in patients with neurodegenerative dementias. |
| Databáze: | OpenAIRE |
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