Facial onset sensory and motor neuronopathy (FOSMN) syndrome responding to immunotherapies
Autor: | Hiroshi Shigeto, Yasumasa Ohyagi, Michiya Uehara, Yuji Kawano, Jun Ichi Kira, Toshihiro Hokonohara |
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Rok vydání: | 2008 |
Předmět: |
Male
medicine.medical_specialty Sensory Receptor Cells Neural Conduction Sensory system medicine Humans Peripheral Nerves FOSMN syndrome Bulbar palsy Motor Neurons Dysesthesia business.industry Snap Middle Aged Deep Tendon Reflex Dysphagia Surgery body regions medicine.anatomical_structure Neurology Scalp Immunotherapy Neurology (clinical) Facial Nerve Diseases medicine.symptom business |
Zdroj: | Journal of the Neurological Sciences. 275:157-158 |
ISSN: | 0022-510X |
DOI: | 10.1016/j.jns.2008.07.021 |
Popis: | We report the first non-Caucasian case of facial onset sensory and motor neuronopathy (FOSMN) syndrome partially responding to various immunotherapies. A 55-year-old man had first felt paresthesia on his right cheek at age 45. This gradually extended to the scalp. Paresthesia of bilateral fingers and dysphagia appeared 6 years later. On admission, facial sensory impairment and bulbar palsy were found. There were no sensory or motor deficits evident in any limb, except for decreased deep tendon reflex and vibratory sensation. Videofluorography (VF) revealed decreased pharyngeal clearance. The sensory nerve action potential (SNAP) amplitudes of median and ulnar nerves were decreased. Intravenous immunoglobulin therapy and plasma exchange ameliorated his dysesthesia and dysphagia after several weeks, and resulted in improvements in VF and SNAP abnormalities. These observations suggest that FOSMN syndrome maybe, in part, immune-mediated. |
Databáze: | OpenAIRE |
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