Gadolinium-based nanoparticles as sensitizing agents to carbon ions in head and neck tumor cells

Autor: Gersende Alphonse, Olivier Tillement, Marie-Thérèse Aloy, Nicolas Magné, Marc Janier, Anne-Sophie Wozny, Michael Beuve, François Lux, Claire Rodriguez-Lafrasse
Přispěvatelé: Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de Cancérologie Lucien Neuwirth, CHU Saint-Etienne, Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Université de Lyon-Université de Lyon
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Models
Molecular
Radiation-Sensitizing Agents
Materials science
Residual double-strand breaks
Gadolinium
[SDV]Life Sciences [q-bio]
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)
Nanoparticle
Carbon ion irradiation
chemistry.chemical_element
Bioengineering
[SDV.CAN]Life Sciences [q-bio]/Cancer
030218 nuclear medicine & medical imaging
Ion
03 medical and health sciences
0302 clinical medicine
Cell Line
Tumor
Relative biological effectiveness
medicine
Humans
General Materials Science
Head and neck
Radiosensitization
business.industry
Head and neck squamous cell carcinoma (HNSCC)
medicine.disease
Head and neck squamous-cell carcinoma
Carbon
3. Good health
chemistry
Head and Neck Neoplasms
Cell culture
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Cancer research
Nanoparticles
Molecular Medicine
Nuclear medicine
business
Gadolinium nanoparticles
Zdroj: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2017, 13 (8), pp.2655-2660. ⟨10.1016/j.nano.2017.07.015⟩
ISSN: 1549-9634
Popis: International audience; Hadrontherapy presents the major advantage of improving tumor sterilization while sparing surrounding healthy tissues because of the particular ballistic (Bragg peak) of carbon ions. However, its efficacy is still limited in the most resistant cancers, such as grade III-IV head and neck squamous cell carcinoma (HNSCC), in which the association of carbon ions with gadolinium-based nanoparticles (AGuIX®) could be used as a Trojan horse. We report for the first time the radioenhancing effect of AGuIX® when combined with carbon ion irradiation in human tumor cells. An increase in relative biological effectiveness (1.7) in three HNSCC cell lines (SQ20B, FaDu, and Cal33) was associated with a significant reduction in the radiation dose needed for killing cells. Radiosensitization goes through a higher number of unrepaired DNA double-strand breaks. These results underline the strong potential of AGuIX® in sensitizing aggressive tumors to hadrontherapy and, therefore, improving local control while lowering acute/late toxicity.
Databáze: OpenAIRE
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