Frequent detection of Saffold cardiovirus in adenoids
| Autor: | Zahrasadat Safavieh, Anna Maria Eis-Hübinger, Ulrike Reber, Friedrich Bootz, Michael Ludwig, Kira Lindner, Stephan Herberhold |
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| Rok vydání: | 2019 |
| Předmět: |
RNA viruses
Male 0301 basic medicine Coronaviruses medicine.medical_treatment Artificial Gene Amplification and Extension Picornaviridae Pathology and Laboratory Medicine Polymerase Chain Reaction Adenoidectomy Families Nasopharynx Genotype Medicine and Health Sciences Child Children Cardiovirus Multidisciplinary biology Saffold virus General Medicine medicine.anatomical_structure Medical Microbiology Human Parainfluenza Viruses Viral Pathogens Child Preschool Viruses Medicine Female Pathogens Anatomy medicine.symptom General Agricultural and Biological Sciences Research Article Science 030106 microbiology Surgical and Invasive Medical Procedures Research and Analysis Methods Adenoid Microbiology Asymptomatic General Biochemistry Genetics and Molecular Biology Throat 03 medical and health sciences Parvoviruses Adeno-Associated Viruses medicine Humans Clinical significance Molecular Biology Techniques Microbial Pathogens Molecular Biology Biology and life sciences business.industry Organisms Reverse Transcriptase-Polymerase Chain Reaction Hypertrophy biology.organism_classification Virology Chronic infection 030104 developmental biology Age Groups Paramyxoviruses People and Places Adenoids Population Groupings Respiratory Syncytial Virus DNA viruses business Neck |
| Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 7, p e0218873 (2019) PLOS ONE |
| ISSN: | 1932-6203 |
| Popis: | Saffold virus (SAFV) is classified into the Cardiovirus genus of the Picornaviridae family. Up to now, eleven genotypes have been identified however, their clinical significance remains unclear. Here, we investigated the presence of SAFV in asymptomatic patients admitted for adenoidectomy. A total of 70 adenoid tissue samples were collected from children with clinical symptoms caused by hypertrophy of adenoids but without symptoms of airway infection. Samples were investigated for SAFV by RT-nested PCR and sequence analysis. Eleven of 70 (15.7%) samples were positive for SAFV. Nasopharyngeal swabs were available from 45 children just before surgery. SAFV was rarely found and only in children with SAFV-positive adenoids 2/8. Our findings indicate that the presence of SAFV seems to be more frequent in adenoid tissue than expected. This could support the notion of a longer than previously anticipated persistence of SAFV nucleic acids in the respiratory tract and possibly a chronic infection. Further investigations are necessary to establish the role of SAFV infection in humans. |
| Databáze: | OpenAIRE |
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