Formation of a salsolinol-like compound, the neurotoxin, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, in a cellular model of hyperglycemia and a rat model of diabetes
| Autor: | Yulin Deng, Hong-Mei Li, Michael Schläppi, Ling-Yan Meng, Nian Xin, Yujuan Li, Bing-Jie Xie, De-Wei Song |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Neurotoxins Carbohydrate metabolism Diabetes Mellitus Experimental Diabetes Complications Superoxide dismutase chemistry.chemical_compound Dopamine Tetrahydroisoquinolines Diabetes mellitus Internal medicine Genetics medicine Animals Neurotoxin Glycolysis biology Hydroxyl Radical business.industry Dopaminergic Neurons Methylglyoxal Dopaminergic Parkinson Disease General Medicine Isoquinolines medicine.disease Rats Disease Models Animal Glucose Endocrinology chemistry Hyperglycemia biology.protein business medicine.drug |
| Zdroj: | International Journal of Molecular Medicine. 33:736-742 |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | There are statistical data indicating that diabetes is a risk factor for Parkinson's disease (PD). Methylglyoxal (MG), a biologically reactive byproduct of glucose metabolism, the levels of which have been shown to be increase in diabetes, reacts with dopamine to form 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ); this formation may provide further insight into the connection between PD and diabetes. In this study, we investigated the role of ADTIQ in these two diseases to determine in an aim to enhance our understanding of the link between PD and diabetes. To this end, a cell model of hyperglycemia and a rat model of diabetes were established. In the cell model of hyperglycemia, compared with the control group, the elevated glucose levels promoted free hydroxyl radical formation (p |
| Databáze: | OpenAIRE |
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