Behavioral assessment of activity-based-anorexia: how cognition can become the drive wheel
| Autor: | Simone Sulpizio, Jubin Abutalebi, Jacopo Lamanna, Riccardo Maria Martoni, Antonio Malgaroli, Mattia Ferro |
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| Přispěvatelé: | Lamanna, J, Sulpizio, S, Ferro, M, Martoni, R, Abutalebi, J, Malgaroli, A, Lamanna, Jacopo, Sulpizio, Simone, Ferro, Mattia, Martoni, Riccardo, Abutalebi, Jubin, Malgaroli, Antonio |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Experimental and Cognitive Psychology
Anorexia Anorexia nervosa 03 medical and health sciences Behavioral Neuroscience Mice 0302 clinical medicine Animal model Cognition medicine Animals Humans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Set (psychology) Behavior fungi 05 social sciences Eating disorder food and beverages Neurophysiology medicine.disease Rats Eating disorders Disease Models Animal ABA Cognitive function medicine.symptom Psychology Neuroscience Neurocognitive 030217 neurology & neurosurgery |
| Popis: | Anorexia Nervosa (AN) is a disorder with a dramatic impact on both the individual and society. Besides severe weight loss, excessive physical exercise and cognitive disturbances can be present in patients with AN as primary symptoms of the pathology or as secondary effects induced by physical and metabolic alterations. Mechanistic research in this field has taken advantage of a well characterized animal model, the activity-based anorexia model (ABA). ABA rodents and subjects with AN show clear behavioral and physiological similarities, but a throughout neurocognitive assessment of the model is still missing. Here, we review the available literature in the ABA field, highlighting similarities between ABA and AN at the behavioral, neurophysiological and cognitive level. Furthermore, based on availability, feasibility and adaptability of rodent behavioral protocols, we propose a set of neurocognitive assays that can be performed on the ABA. The proposed assessment represents an important step forward in the validation and extension of the ABA model, opening several routes of investigation related to AN and other eating disorders. |
| Databáze: | OpenAIRE |
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