Structural insights into actin-binding, branching and bundling proteins
| Autor: | Steven J. Winder |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
biology
Macromolecular Substances Microfilament Proteins Arp2/3 complex Actin remodeling macromolecular substances Cell Biology Actin cytoskeleton Filamentous actin MreB Protein Structure Tertiary Cell biology Prokaryotic cytoskeleton Actin Cytoskeleton Cytoskeletal Proteins Eukaryotic Cells Actin-Related Protein 2 biology.protein Animals Humans Protein Structure Quaternary Cytoskeleton Actin |
| Zdroj: | Current Opinion in Cell Biology. 15:14-22 |
| ISSN: | 0955-0674 |
| Popis: | Structural advances in our understanding of the functions of the actin cytoskeleton have come from diverse sources. On the one hand, the determination of the structure of a bacterial actin-like protein MreB reveals the prokaryotic origins of the actin cytoskeleton, whereas on the other, cryo-electron microscopy and crystallography have yielded reconstructions of many actin crosslinking, regulatory and binding proteins in complex with F-actin. Not least, a high-resolution structure of the Arp2/3 complex and a reconstruction with F-actin provides considerable insight into the eukaryotic machinery, vital for the formation of new F-actin barbed ends, a prerequisite for rapid actin polymerisation involved in cell shape change and motility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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