Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis

Autor: Hannah Melchinger, Frida Calderon-Gutierrez, Wassim Obeid, Leyuan Xu, Melissa M. Shaw, Randy L. Luciano, Michael Kuperman, Gilbert W. Moeckel, Michael Kashgarian, F. Perry Wilson, Chirag R. Parikh, Dennis G. Moledina
Rok vydání: 2022
Předmět:
Zdroj: Clinical Journal of the American Society of Nephrology. 17:1284-1292
ISSN: 1555-905X
1555-9041
DOI: 10.2215/cjn.04360422
Popis: Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the kidney tubulointerstitium has not been characterized. In this study, we test the association of urine uromodulin with kidney histologic findings in humans and mice.We investigated the independent association of urine uromodulin measured at the time of kidney biopsy with histologic features in 364 participants at two academic medical centers from 2015 to 2018 using multivariable linear regression models. This relationship was further examined by comparison of uromodulin staining in murine models of kidney fibrosis and repair.We found urine uromodulin to be correlated with serum creatinine (rho=-0.43;Higher urine uromodulin is independently associated with lower tubulointerstitial fibrosis in both human kidney biopsies and a mouse model of fibrosis.This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_08_10_CJN04360422.mp3.
Databáze: OpenAIRE