The influence of diuretics on the excretion and metabolism of doping agents: Part VI. Pseudoephedrine
| Autor: | F. T. Delbeke, M. Debackere |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Chromatography
Gas Metabolite medicine.medical_treatment Pharmaceutical Science Urine Excretion chemistry.chemical_compound Oral administration medicine Humans Pharmacology (medical) Diuretics Bumetanide Ephedrine Pharmacology Fluorocarbons Chromatography Water General Medicine Pseudoephedrine Acetazolamide Nasal decongestant chemistry Diuretic medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 12:37-48 |
| ISSN: | 1099-081X 0142-2782 |
| Popis: | A capillary gas chromatographic method with nitrogen specific detection is presented for measuring pseudoephedrine and its major metabolite norpseudoephedrine in urine after derivatization with trifluoroacetic anhydride. After the oral intake of 49·2 mg pseudoephedrine (ACTIFED®) the active substance is nearly quantitatively excreted in urine over a 48 hr period. From 1 to 7 per cent is metabolized to norpseudoephedrine. The intake of acetazolamide results in a suppression of the pseudoephedrine concentration for at least 12h. The diuretic effect after the intake of 1·51 mineral water could be compared with the effect obtained with 1 mg bumetanide and results in a decrease in pseudoephedrine concentration by a factor 4 for several hours. |
| Databáze: | OpenAIRE |
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