Clinical and histopathological features of adult patients with dermatomyositis and melanoma differentiation associated-5 autoantibody seropositivity status, as determined by commercially available testing: a retrospective, single-institution comparative cohort study
| Autor: | Lisa A. Drage, Julia S. Lehman, H Shakshouk, David A. Wetter, M A Deschaine, F. C. Ernste |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Interferon-Induced Helicase IFIH1 Biopsy Dermatology Malignancy Gastroenterology Dermatomyositis Internal medicine medicine Humans skin and connective tissue diseases Myopathy Autoantibodies Retrospective Studies Skin medicine.diagnostic_test business.industry Autoantibody Raynaud Disease medicine.disease Dysphagia Skin biopsy Female medicine.symptom business Deglutition Disorders Cohort study Spongiosis |
| Zdroj: | Clinical and experimental dermatologyReferences. 47(2) |
| ISSN: | 1365-2230 |
| Popis: | BACKGROUND Although melanoma differentiation associated (MDA)-5 autoantibodies have been widely explored in dermatomyositis (DM), most studies have relied on MDA-5 autoantibody testing performed in research settings, rather than the now-available commercial laboratory tests. AIM To characterize the clinical and histopathological data in patients with DM and circulating MDA-5 autoantibodies, as defined by commercially available testing. METHODS This was a retrospective review of patients with DM who underwent MDA-5 antibody testing. All available skin biopsy slides were reviewed. RESULTS Cutaneous features more prevalent in MDA-5-positive DM included Raynaud phenomenon (RP) (P |
| Databáze: | OpenAIRE |
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