Alginate coating modifies the biological effects of cerium oxide nanoparticles to the freshwater bivalve Dreissena polymorpha
| Autor: | Fiorenza Farè, Andrea Binelli, Stefano Magni, Matteo Chiara, Lara Nigro, Giuseppe Protano, Nicoletta Riccardi, Donatella Caruso, Hady Hamza, Daniela Maggioni, Camilla Della Torre, Manuela Fontana |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Environmental Engineering
Freshwater bivalve 010504 meteorology & atmospheric sciences Alginates Dreissena polymorpha Fresh Water 010501 environmental sciences 01 natural sciences Dreissena Alginate coating Chitosan Superoxide dismutase chemistry.chemical_compound Osmoregulation Animals Humans Environmental Chemistry Metabolomics Eco-corona Waste Management and Disposal 0105 earth and related environmental sciences chemistry.chemical_classification Reactive oxygen species biology biological effects cerium oxide nanoparticles Cerium Metabolism biology.organism_classification Pollution Cerium oxide nanoparticles Eco-corona Oxidative stress Metabolomics Osmoregulation chemistry Osmolyte Oxidative stress biology.protein Biophysics Nanoparticles Ecotoxicity Water Pollutants Chemical |
| Zdroj: | Science of the total environment 773 (2021). doi:10.1016/j.scitotenv.2021.145612 info:cnr-pdr/source/autori:Della Torre C.; Maggioni D.; Nigro L.; Fare F.; Hamza H.; Protano G.; Magni S.; Fontana M.; Riccardi N.; Chiara M.; Caruso D.; Binelli A./titolo:Alginate coating modifies the biological effects of cerium oxide nanoparticles to the freshwater bivalve Dreissena polymorpha/doi:10.1016%2Fj.scitotenv.2021.145612/rivista:Science of the total environment/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:773 |
| DOI: | 10.1016/j.scitotenv.2021.145612 |
| Popis: | The adsorption of biomacromolecules is a fundamental process that can alter the behaviour and adverse effects of nanoparticles (NPs) in natural systems. While the interaction of NPs with natural molecules present in the environment has been described, their biological impacts are largely unknown. Therefore, this study aims to provide a first evidence of the influence of biomolecules sorption on the toxicity of cerium oxide nanoparticles (CeO2NPs) towards the freshwater bivalve Dreissena polymorpha. To this aim, we compared naked CeO2NPs and coated with alginate and chitosan, two polysaccharides abundant in aquatic environments. Mussels were exposed to the three CeO2NPs (naked, chitosan- and alginate-coated) up to 14 days at 100 μg L−1, which is a concentration higher than the environmental one predicted for this type of NP. A suite of biomarkers related to oxidative stress and energy metabolism was applied, and metabolomics was also carried out to identify metabolic pathways potentially targeted by CeO2NPs. Results showed that the coating with chitosan reduced NP aggregation and increased the stability in water. Nonetheless, the Ce accumulation in mussels was similar in all treatments. As for biological effects, all three types of CeO2NPs reduced significantly the level of reactive oxygen species and the activity of superoxide dismutase, glutathione peroxidase and glutathione-S-transferase. The effect was more pronounced in individuals exposed to CeO2NPs coated with alginate, which also significantly induced the activity of the electron transport system. Metabolomics analysis of amino acid metabolism showed modulation only in mussels treated with CeO2NPs coated with alginate. In this group, 25 metabolites belonging to nucleotides, lipids/sterols and organic osmolytes were also modulated, suggesting that the nanoparticles affect energetic metabolism and osmoregulation of mussels. This study highlights the key role of the interaction between nanoparticles and natural molecules as a driver of nanoparticle ecotoxicity. |
| Databáze: | OpenAIRE |
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