Autaptic Connections Shift Network Excitability and Bursting
| Autor: | Laura Wiles, Brandon Parvesse, Danielle S. Bassett, David F. Meaney, Fabio Pasqualetti, Shi Gu, David Gabrieli |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Physics Neurons Multidisciplinary Models Neurological Action Potentials Neurotransmission Neurophysiology Synaptic Transmission Article Controllability 03 medical and health sciences Bursting 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Inhibitory synapses medicine Excitatory postsynaptic potential Premovement neuronal activity Computer Simulation Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if controllability significantly affects changes in bursting from autaptic connections. Adding more autaptic connections to excitatory neurons increased the number of spiking events and the number of network-wide bursts. We observed excitatory synapses contributed more to bursting behavior than inhibitory synapses. We evaluated if neurons with high average controllability, predicted to push the network into easily achievable states, affected bursting behavior differently than neurons with high modal controllability, thought to influence the network into difficult to reach states. Results show autaptic connections to excitatory neurons with high average controllability led to higher burst frequencies than adding the same number of self-looping connections to neurons with high modal controllability. The number of autapses required to induce bursting was lowered by adding autapses to high degree excitatory neurons. These results suggest a role of autaptic connections in controlling network-wide bursts in diverse cortical and subcortical regions of mammalian brain. Moreover, they open up new avenues for the study of dynamic neurophysiological correlates of structural controllability. |
| Databáze: | OpenAIRE |
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