GLC determination of cyclobenzaprine in plasma and urine
| Autor: | Susan C. Stauffer, Howard B. Hucker |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Drug
Chromatography Chromatography Gas Time Factors Chemistry Metabolite media_common.quotation_subject Extraction (chemistry) Pharmaceutical Science Administration Oral Ether Alcohol Urine Plasma levels Dibenzocycloheptenes chemistry.chemical_compound Cyclobenzaprine Injections Intravenous medicine Methods Humans medicine.drug media_common |
| Zdroj: | Journal of pharmaceutical sciences. 65(8) |
| ISSN: | 0022-3549 |
| Popis: | A GLC determination of cyclobenzaprine in human plasma and urine is described. After extraction from alkalinized samples with heptane-isopentyl alcohol (97:3), the drug and internal standard were back-extracted into 0.1 N HCl and then reextracted into ether. Use of a lower homolog of the drug as an internal standard was effective in reducing variability. Drug concentrations as low as 25 ng/ml could be assayed with high precision. Plasma levels in humans given 40 mg po or iv ranged from 5 to 51 ng/ml; little unchanged cyclobenzaprine was present in the urine. The N-desmethyl analog of the drug was detected as a metabolite in urine. |
| Databáze: | OpenAIRE |
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