Correlation of the degree of dyspnea with health-related quality of life, functional abilities, and diffusing capacity for carbon monoxide in patients with systemic sclerosis and active alveolitis: Results from the scleroderma lung study
| Autor: | Arthur C. Theodore, Mildred Sterz, Donald P. Tashkin, John Varga, Robert Elashoff, Dinesh Khanna, Michael D. Roth, Jerry A. Molitor, M. Kari Connolly, Fredrick M. Wigley, Philip J. Clements, Virginia D. Steen, B. J. Fessler, James R. Seibold, Yun Chon, Kamal K. Mubarak, Richard M. Silver, John FitzGerald, Joannie Chung, Daniel E. Furst, Naomi F. Rothfield, Maureen D. Mayes |
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| Rok vydání: | 2005 |
| Předmět: |
Lung Diseases
Male Vital capacity medicine.medical_specialty Health Status Vital Capacity Immunology Population Pulmonary function testing Pulmonary Disease Chronic Obstructive FEV1/FVC ratio Double-Blind Method Rheumatology DLCO Surveys and Questionnaires Internal medicine Diffusing capacity Humans Immunology and Allergy Medicine Pharmacology (medical) education Carbon Monoxide COPD education.field_of_study Scleroderma Systemic business.industry Baseline Dyspnea Index Middle Aged respiratory system medicine.disease Respiratory Function Tests Pulmonary Alveoli Dyspnea Quality of Life Cardiology Physical therapy Pulmonary Diffusing Capacity Female business |
| Zdroj: | Arthritis & Rheumatism. 52:592-600 |
| ISSN: | 1529-0131 0004-3591 |
| DOI: | 10.1002/art.20787 |
| Popis: | Objective To determine whether baseline self-assessment measures of health status and physiologic indices of disease severity in alveolitis-positive patients with systemic sclerosis (SSc) correlate with the severity of their dyspnea, and to quantify functional impairment in patients with scleroderma lung disease and compare it with that in patients with chronic obstructive pulmonary disease (COPD). Methods SSc patients (n = 138) with diffuse (n = 81) or limited (n = 57) cutaneous disease and active alveolitis (determined by bronchoalveolar lavage and/or high-resolution computed tomography) who participated in the National Heart, Lung, and Blood Institute–sponsored, multicenter, parallel-group, double-blind, randomized, placebo-controlled trial of oral cyclophosphamide for treatment of SSc-associated interstitial lung disease were evaluated. Pearson's univariate correlations were determined between the Short Form 36 (SF-36) physical component summary (PCS) and mental component summary (MCS) scales, functional questionnaires, and physiologic parameters of breathing (forced vital capacity [FVC] and single-breath diffusing capacity for carbon monoxide [DLCO]). Student's t-test was used to compare subgroups. Scores from 2 instruments for self-assessment of breathlessness, Mahler's baseline dyspnea index (BDI) and a visual analog scale (VAS) for breathing, were divided at the median. Values for the DLCO and FVC (% predicted) were divided based on the American Thoracic Society guidelines for mild (>70% of predicted), moderate (50–70% of predicted), and severe ( |
| Databáze: | OpenAIRE |
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