Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade
| Autor: | Yoshitsugu Inoue, Fu-Tong Liu, Dai Miyazaki, Atsuki Fukushima, Marc E. Rothenberg, Takeshi Tominaga, Takao Nakamura, Masaharu Ohbayashi, Hidemitsu Higashi, Chuan Hui Kuo, Santa Jeremy Ono, Meguru Murata, Shuzo Takeda, Naoki Komatsu, Keiko Yakura |
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| Rok vydání: | 2009 |
| Předmět: |
Chemokine CCL11
Receptors CCR3 Immunology CCR3 Biology Immunoglobulin E Cell Degranulation Mice Chemokine receptor Immune system immune system diseases medicine Animals Immunology and Allergy Mast Cells Conjunctivitis Allergic Glycoproteins Skin Mice Knockout Mice Inbred BALB C Vaccination Degranulation hemic and immune systems General Medicine Allergens medicine.disease Mast cell Allergic conjunctivitis medicine.anatomical_structure Cats biology.protein Featured Article of the Month Conjunctiva Signal Transduction Type I hypersensitivity |
| Zdroj: | International Immunology. 21:187-201 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/dxn137 |
| Popis: | The immune response is regulated, in part, by effector cells whose activation requires multiple signals. For example, T cells require signals emanating from the T cell antigen receptor and co-stimulatory molecules for full activation. Here, we present evidence indicating that IgE-mediated hypersensitivity reactions in vivo also require cognate signals to activate mast cells. Immediate hypersensitivity reactions in the conjunctiva are ablated in mice deficient in eotaxin-1, despite normal numbers of tissue mast cells and levels of IgE. To further define the co-stimulatory signals mediated by chemokine receptor 3 (CCR3), an eotaxin-1 receptor, effects of CCR3 blockade were tested with an allergic conjunctivitis model and in ex vivo isolated connective tissue-type mast cells. Our results show that CCR3 blockade significantly suppresses allergen-mediated hypersensitivity reactions as well as IgE-mediated mast cell degranulation. We propose that a co-stimulatory axis by CCR3, mainly stimulated by eotaxin-1, is pivotal in mast cell-mediated hypersensitivity reactions. |
| Databáze: | OpenAIRE |
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