A minor subset of HLA-DR3 haplotypes is preferentially increased in Type 1 (insulin-dependent) diabetes
| Autor: | T C Fuller, J.R. Rowe, M J Sheehy, Edmond J. Yunis, Kenneth H. Gabbay |
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| Rok vydání: | 1985 |
| Předmět: |
Genetic Linkage
T-Lymphocytes Endocrinology Diabetes and Metabolism Genes MHC Class II HLA-DR3 Human leukocyte antigen Cell Line HLA-DR3 Antigen Antigen Diabetes mellitus Internal Medicine medicine Humans Allele Alleles Genetics MHC class II Type 1 diabetes biology Haplotype Histocompatibility Antigens Class II medicine.disease Clone Cells Diabetes Mellitus Type 1 Immunology biology.protein |
| Zdroj: | Diabetologia. 28:891-894 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf00703131 |
| Popis: | We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1- DR3 haplotypes. Alternative interpretations are also discussed. |
| Databáze: | OpenAIRE |
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