Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study
| Autor: | L. F. D. van Vulpen, G. Roosendaal, M.E. van Meegeren, Roger E. G. Schutgens, N.W. Jansen, J.M. van Laar, S.C. Mastbergen, F.P.J.G. Lafeber |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Urinary system Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] Biomedical Engineering Arthropathy Urine Hemophilia A Research Support Gastroenterology Autologous blood injection Haemarthrosis Young Adult Dogs N-terminal telopeptide Rheumatology Internal medicine Hemarthrosis Journal Article Animals Humans Medicine Orthopedics and Sports Medicine Non-U.S. Gov't Aged Cartilage oligomeric matrix protein Medicine(all) biology business.industry Research Support Non-U.S. Gov't Biochemical markers Middle Aged Bleed medicine.disease Surgery Cartilage biology.protein Female Joint Diseases business Biomarkers |
| Zdroj: | Osteoarthritis and Cartilage, 23, 1, pp. 63-9 Osteoarthritis and Cartilage, 23, 63-9 Osteoarthritis and Cartilage, 23(1), 63. W.B. Saunders Ltd |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2014.09.008 |
| Popis: | Item does not contain fulltext OBJECTIVE: Evaluation whether biomarkers of joint damage are sensitive to change shortly after a joint bleed in hemophilia patients and in a canine model of blood-induced joint damage. METHODS: Blood and urine samples were collected from 10 hemophilia patients after they reported a joint bleed: within 2 days, after 3-5 days, and 12-14 days. Additionally, 90 days after the bleed a blood and urine sample was taken and considered to represent baseline condition. Commercial serum and urine biomarker assays were performed: urinary C-terminal telopeptide of type II collagen (uCTX-II), serum cartilage oligomeric matrix protein (sCOMP), serum cartilage cleavage product C1,2C, and serum chondroitin sulfate 846 (sCS846). The same panel of biomarkers was explored in dogs (n = 7) after induction of a first joint bleed by intra-articular blood injections. Biosamples were collected at baseline, day 2, 1 and 2 weeks later. RESULTS: In hemophilia patients, levels of uCTX-II and sCS846 increased 5 days after joint bleeding when compared with baseline (+52%; P = 0.021 and +14%; P = 0.011, respectively). In dogs, uCTX-II increased statistically significant from day 2 to day 7 (from 75% to 155% of baseline; P = 0.018), and sCOMP from baseline to day 2 (+46%; P = 0.028). CONCLUSIONS: This study demonstrates that biochemical markers of joint tissue damage increase shortly after a single joint bleed, both in humans with established hemophilic arthropathy (HA) and in an animal model of joint damage upon a first joint bleed. Biomarkers might be useful in monitoring the impact of a joint bleed and in evaluation of treatment of such bleeds. |
| Databáze: | OpenAIRE |
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