The impact of tube replacement timing during LCIG therapy on PEG-J associated adverse events: a retrospective multicenter observational study
| Autor: | Kazuhiro Furukawa, Yukinao Yamazaki, Tomoyuki Koike, Yoshinori Sato, Shinsuke Fujioka, Takehide Fukuchi, Tomohiko Suzuki, Takeshi Uehara, Kanefumi Yamashita, Yukinori Yube, Hidehiro Murakami, Masaki Kato, Yoshiou Ikeda, Xiaoyi Jin, Eiji Kubota, Yoshio Tsuboi, Satoshi Furune |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Gastric Bypass Antiparkinson Agents Levodopa 03 medical and health sciences 0302 clinical medicine medicine Health insurance Humans In patient Adverse effect RC346-429 Retrospective Studies medicine.diagnostic_test business.industry Research Incidence (epidemiology) Carbidopa Parkinson Disease General Medicine Endoscopy Surgery Drug Combinations Levodopa–carbidopa intestinal gel Percutaneous [endoscopic] gastrojejunostomy Parkinson’s disease 030211 gastroenterology & hepatology Observational study Neurology (clinical) Neurosurgery Neurology. Diseases of the nervous system Percutaneous endoscopic gastrojejunostomy business Gels 030217 neurology & neurosurgery |
| Zdroj: | BMC Neurology, Vol 21, Iss 1, Pp 1-7 (2021) BMC Neurology |
| ISSN: | 1471-2377 |
| Popis: | Background Levodopa–carbidopa intestinal gel (LCIG) treatment, a unique drug delivery system for patients with advanced Parkinson’s disease (PD), is covered by health insurance in Japan since September 2016. Various LCIG procedure/device-associated adverse events (AEs) have been reported; however, reports on their treatment have been limited. This is the first multicenter study to clarify the frequency and timing of device-related AEs. Methods Between September 2016 and December 2018, 104 patients introduced to the LCIG treatment for advanced PD in 11 hospitals were included. The patients’ characteristics, AEs incidence, AEs time, and tube exchange time were investigated. Results The median follow-up period was 21.5 months. Minor AE cases were 29.4%, whereas major AE cases were 43.1%. Majority of major AEs (n = 55, 94.8%) were managed with endoscopic treatment, such as tube exchange. Few severe AEs required surgical treatment (n =3, 5.2%). The mean (range) exposure to percutaneous endoscopic gastrojejunostomy (PEG-J) was 14.7 (0–33) months. One year after the LCIG treatment introduction, 55 patients (54.0%) retained the original PEG-J tube. The mean PEG-J tube exchange time was 10.8 ± 7.0 months in all patients, 11.6 ± 4.7 and 10.5 ± 7.7 months in patients with scheduled exchange and who underwent exchange due to AEs, respectively. Conclusions Some device-related AEs occurred during the LCIG treatment; however, only few were serious, most of which could be treated with simple procedures or tube replacement with endoscopy. Therefore, the LCIG treatment is feasible and safe and is a unique treatment option for PD, requiring endoscopists’ understanding and cooperation. |
| Databáze: | OpenAIRE |
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