Elimination of Mother-To-Child Transmission of HIV Infection: The Drug Resource Enhancement against AIDS and Malnutrition Model
| Autor: | Marco Peroni, Kebby Musokotwane, Bernard N. B. Bossiky, Khethimipilo E. Mothibi, Karin Nielsen-Saines, P Germano, Pasquale Narciso, Andrea De Luca, Giuseppe Liotta, Ines Zimba, Stefano Orlando, Paola Scarcella, Nurja A. Magid, Esther K. Bonje, Maria Cristina Marazzi, Sandro Mancinelli, Elard Alumando, Giovanni Guidotti, Sangare H. Mamary, Leonardo Palombi, Ersilia Buonomo, Evelyne E. Amangoua, Precious A. Robinson |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty Anti-HIV Agents Health Toxicology and Mutagenesis Settore MED/42 - Igiene Generale e Applicata Population Breastfeeding lcsh:Medicine Mothers HIV Infections Review DREAM program elimination of HIV MTCT Settore MED/17 - MALATTIE INFETTIVE Social support Acquired immunodeficiency syndrome (AIDS) Pregnancy medicine Humans Pregnancy Complications Infectious education Child Africa South of the Sahara education.field_of_study Acquired Immunodeficiency Syndrome business.industry Transmission (medicine) lcsh:R Malnutrition Public Health Environmental and Occupational Health virus diseases Models Theoretical medicine.disease Infant mortality Infectious Disease Transmission Vertical HIV-1 Health education Female business |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 12, Iss 10, Pp 13224-13239 (2015) |
| Popis: | The Drug Resource Enhancement against AIDS and Malnutrition Program (DREAM) gathered professionals in the field of Elimination of HIV-Mother-To-Child Transmission (EMTCT) in Maputo in 2013 to discuss obstacles and solutions for the elimination of HIV vertical transmission in sub-Saharan Africa. During this workshop, the benefits of administrating combined antiretroviral therapy (cART) to HIV positive women from pregnancy throughout breastfeeding were reviewed. cART is capable of reducing vertical transmission to less than 5% at 24 months of age, as well as maternal mortality and infant mortality in both HIV infected and exposed populations to levels similar to those of uninfected individuals. The challenge for programs targeting eMTCT in developing countries is retention in care and treatment adherence. Both are intrinsically related to the model of care. The drop-out from eMTCT programs before cART initiation ranges from 33%–88% while retention rates at 18–24 months are less than 50%. Comprehensive strategies including peer-to-peer education, social support and laboratory monitoring can reduce refusals to less than 5% and attain retention rates approaching 90%. Several components of the model of care for reduction of HIV-1 MTCT are feasible and implementable in scale-up strategies. A review of this model of care for HIV eMTCT is provided. |
| Databáze: | OpenAIRE |
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