Revisiting prostate cancer metabolism: From metabolites to disease and therapy
| Autor: | Marília I. Figueira, Lara R. S. Fonseca, Sílvia Socorro, Cátia V. Vaz, Henrique J. Cardoso, Tiago M.A. Carvalho |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Bioenergetics Metabolic reprogramming Cancer therapy Disease Bioinformatics 03 medical and health sciences Prostate cancer 0302 clinical medicine Drug Discovery medicine Humans 030304 developmental biology Pharmacology 0303 health sciences business.industry Prostatic Neoplasms Oncogenes Metabolism medicine.disease Glutamine Metabolic pathway 030220 oncology & carcinogenesis Molecular Medicine business Metabolic Networks and Pathways |
| Zdroj: | Medicinal Research Reviews. 41:1499-1538 |
| ISSN: | 1098-1128 0198-6325 |
| DOI: | 10.1002/med.21766 |
| Popis: | Prostate cancer (PCa), one of the most commonly diagnosed cancers worldwide, still presents important unmet clinical needs concerning treatment. In the last years, the metabolic reprogramming and the specificities of tumor cells emerged as an exciting field for cancer therapy. The unique features of PCa cells metabolism, and the activation of specific metabolic pathways, propelled the use of metabolic inhibitors for treatment. The present work revises the knowledge of PCa metabolism and the metabolic alterations that underlie the development and progression of the disease. A focus is given to the role of bioenergetic sources, namely, glucose, lipids, and glutamine sustaining PCa cell survival and growth. Moreover, it is described as the action of oncogenes/tumor suppressors and sex steroid hormones in the metabolic reprogramming of PCa. Finally, the status of PCa treatment based on the inhibition of metabolic pathways is presented. Globally, this review updates the landscape of PCa metabolism, highlighting the critical metabolic alterations that could have a clinical and therapeutic interest. |
| Databáze: | OpenAIRE |
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