Bent Oligonucleotide Duplexes as HMGB1 Inhibitors: a Comparative Study

Autor:	Giovanni N. Roviello, Silvano Fumero, Margherita Valente, Enrico M. Bucci, Maria Moccia, Carlo Pedone, Roberto Sapio, Domenica Musumeci
Přispěvatelé:	Musumeci, D, Roviello, Gn, Moccia, M, Pedone, Carlo, Bucci, Em, Sapio, R, Valente, M, Fumero, S., Musumeci, Domenica, G. N., Roviello, M., Moccia, E. M., Bucci, R., Sapio, M., Valente, S., Fumero
Rok vydání:	2007
Předmět:	Dna duplex biology Oligonucleotide Stereochemistry Bent molecular geometry Oligonucleotides A protein DNA General Medicine HMGB1 Biochemistry chemistry.chemical_compound LNA chemistry Duplex (building) Genetics biology.protein Humans Molecular Medicine bent duplexes HMGB1 Protein HMGB1 inhibition
Zdroj:	Nucleosides, nucleotides & nucleic acids 26 (2007): 1447–1450. doi:10.1080/15257770701542330 info:cnr-pdr/source/autori:D. Musumeci; E.M. Bucci; M. Moccia; G.N. Roviello; R. Sapio; M. Valente; C. Pedone; S. Fumero/titolo:Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study/doi:10.1080%2F15257770701542330/rivista:Nucleosides, nucleotides & nucleic acids/anno:2007/pagina_da:1447/pagina_a:1450/intervallo_pagine:1447–1450/volume:26
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770701542330
Popis:	In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29163b58fc1d37093abc86c938ec9ff https://doi.org/10.1080/15257770701542330 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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