Phase I studies with carboplatin at the Royal Marsden Hospital
| Autor: | Ah Calvert, David R. Newell, Zahid H Siddik, Sj Harland, Kr Harrap |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Organoplatinum Compounds Nausea Vomiting Renal function Antineoplastic Agents Kidney Gastroenterology Nephrotoxicity Carboplatin chemistry.chemical_compound Ototoxicity Pharmacokinetics Internal medicine Neoplasms Medicine Humans Radiology Nuclear Medicine and imaging Cisplatin business.industry Ear General Medicine medicine.disease Thrombocytopenia Kinetics Oncology chemistry Drug Evaluation medicine.symptom business medicine.drug Glomerular Filtration Rate |
| Zdroj: | Cancer treatment reviews. 12 |
| ISSN: | 0305-7372 |
| Popis: | Carboplatin was evaluated in a Phase I and pharmacokinetic study at the Royal Marsden Hospital between April 1981 and November 1981. Sixty patients were entered of whom 16 had impaired renal function. No evidence of ototoxicity or nephrotoxicity was found. Nausea and vomiting were much reduced compared to cisplatin. The dose limiting toxicity was delayed myelosuppression with thrombocytopenia being more severe than leucopenia. A number of clinical responses were seen, particularly in patients with ovarian carcinoma. Pharmacokinetic studies suggested that the dose of JM8 should be adjusted according to the glomerular filtration rate. |
| Databáze: | OpenAIRE |
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