Regulation of auditory plasticity during critical periods and following hearing loss
| Autor: | Dora Persic, David K. Ryugo, Sonja J. Pyott, Vassilis Pelekanos, Maryse E. Thomas, Katrin Krumbholz, Anne E. Takesian |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Auditory Pathways Neuronal reorganization Hearing loss Review Article Biology Plasticity Deafness Auditory cortex Sensory deprivation 03 medical and health sciences Tinnitus 0302 clinical medicine Hidden hearing loss medicine Biological neural network Humans Developmental critical periods Neuronal Plasticity medicine.disease Sensory Systems 030104 developmental biology Synaptopathy Sensory maps medicine.symptom Auditory brainstem Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Hearing Research |
| ISSN: | 0378-5955 |
| DOI: | 10.1016/j.heares.2020.107976 |
| Popis: | Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both developmental critical periods—when plasticity facilitates the optimization of neural circuits in concert with the external environment—and in adulthood—when hearing loss is linked to the generation of tinnitus. In this review, we summarize research identifying the molecular, cellular, and circuit-level mechanisms regulating neuronal organization and tonotopic map plasticity during developmental critical periods and in adulthood. These mechanisms are shared in both the juvenile and adult brain and along the length of the auditory pathway, where they serve to regulate disinhibitory networks, synaptic structure and function, as well as structural barriers to plasticity. Regulation of plasticity also involves both neuromodulatory circuits, which link plasticity with learning and attention, as well as ascending and descending auditory circuits, which link the auditory cortex and lower structures. Further work identifying the interplay of molecular and cellular mechanisms associating hearing loss-induced plasticity with tinnitus will continue to advance our understanding of this disorder and lead to new approaches to its treatment. Highlights • During CPs, brain plasticity is enhanced and sensitive to acoustic experience. • Enhanced plasticity can be reinstated in the adult brain following hearing loss. • Molecular, cellular, and circuit-level mechanisms regulate CP and adult plasticity. • Plasticity resulting from hearing loss may contribute to the emergence of tinnitus. • Modifying plasticity in the adult brain may offer new treatments for tinnitus. |
| Databáze: | OpenAIRE |
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