Gene-target recognition among members of the myc superfamily and implications for oncogenesis
| Autor: | Ronald A. DePinho, Ken Chen, Cole T. Thomson, James C. Sacchettini, Richard Schwab, Ronan C. O'hagan, Nicole Schreiber-Agus, Jeffrey A. Engelman, Leila Alland, Donald R. Ronning, Paul S. Meltzer, Gregory David |
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| Rok vydání: | 2000 |
| Předmět: |
Models
Molecular Cell Survival Protein Conformation Common gene Molecular Sequence Data Apoptosis Biology medicine.disease_cause Transfection Cell Line Proto-Oncogene Proteins c-myc Mice Gene expression Genetics medicine Basic Helix-Loop-Helix Transcription Factors Animals Humans Amino Acid Sequence Gene Conserved Sequence Gene targets Sequence Homology Amino Acid Mechanism (biology) Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Tumor Suppressor Proteins Helix-Loop-Helix Motifs SUPERFAMILY 3T3 Cells Recombinant Proteins Cell biology DNA-Binding Proteins Repressor Proteins Cell Transformation Neoplastic Gene Expression Regulation Carcinogenesis Sequence Alignment Cell Division Transcription Factors |
| Zdroj: | Nature genetics. 24(2) |
| ISSN: | 1061-4036 |
| Popis: | Myc and Mad family proteins regulate multiple biological processes through their capacity to influence gene expression directly. Here we show that the basic regions of Myc and Mad proteins are not functionally equivalent in oncogenesis, have separable E-box-binding activities and engage both common and distinct gene targets. Our data support the view that the opposing biological actions of Myc and Mxi1 extend beyond reciprocal regulation of common gene targets. Identification of differentially regulated gene targets provides a framework for understanding the mechanism through which the Myc superfamily governs the growth, proliferation and survival of normal and neoplastic cells. |
| Databáze: | OpenAIRE |
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