The Effect of -9-Tetrahydrocannabinol on Rat Cerebrospinal Fluid
| Autor: | G J DiGregorio, Charles B. Brill, A C Mancall, E Ruch |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.diagnostic_test Chemistry organic chemicals Rats Inbred Strains Pharmacology Ventricular system Csf flow Rats Cerebrospinal fluid Arts and Humanities (miscellaneous) mental disorders medicine Animals Ketamine Dronabinol Neurology (clinical) Sympathomimetic Effects Tetrahydrocannabinol Cisternal puncture Cerebrospinal Fluid medicine.drug |
| Zdroj: | Archives of Neurology. 42:1069-1071 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.1985.04060100051021 |
| Popis: | The effect of delta-9-tetrahydrocannabinol (THC) on cerebrospinal fluid (CSF) flow in rats was studied. The ventricular system of rats anesthetized with ketamine sulfate was cannulated via cisternal puncture, and CSF production was recorded. When administered in doses of 25 mg/kg to 45 mg/kg intraperitoneally, THC caused inhibition of CSF flow; in larger doses a smaller response was noted. In response to THC, CSF flow showed an initial drop, a return toward baseline, and a secondary decrease. It is postulated that this biphasic effect is due to a combination of THC's sympathomimetic effects on the CNS plus the local action that this drug has on choroidal synaptosomal neurotransmitters. |
| Databáze: | OpenAIRE |
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