The RNA Atlas expands the catalog of human non-coding RNAs

Autor: Eric James de Bony, Aidan P. Tay, Justine Nuytens, Steve Lefever, Tim De Meyer, Marieke Vromman, Pieter Mestdagh, Tine Goovaerts, Nandan P. Deshpande, Stephen M. Gross, Katleen De Preter, Lucia Lorenzi, Jo Vandesompele, Nele Nijs, Pieter-Jan Volders, Jørgen Kjems, Scott Kuersten, Pavel Sumazin, Francisco Avila Cobos, Wim Trypsteen, Jasper Anckaert, Katrien Vanderheyden, Govardhan Anande, Marc R. Wilkins, Ken R. Bracke, Ting-Wen Chen, Robrecht Cannoodt, Tom Taghon, Yvan Saeys, Thomas B. Hansen, Fien Gysens, Hua-Sheng Chiu, Jan Koster, Karim Vermaelen, Gary P. Schroth, Ashwin Unnikrishnan
Přispěvatelé: Oncogenomics, CCA - Cancer biology and immunology
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Lorenzi, L, Chiu, H S, Avila Cobos, F, Gross, S, Volders, P J, Cannoodt, R, Nuytens, J, Vanderheyden, K, Anckaert, J, Lefever, S, Tay, A P, de Bony, E J, Trypsteen, W, Gysens, F, Vromman, M, Goovaerts, T, Hansen, T B, Kuersten, S, Nijs, N, Taghon, T, Vermaelen, K, Bracke, K R, Saeys, Y, De Meyer, T, Deshpande, N P, Anande, G, Chen, T W, Wilkins, M R, Unnikrishnan, A, De Preter, K, Kjems, J, Koster, J, Schroth, G P, Vandesompele, J, Sumazin, P & Mestdagh, P 2021, ' The RNA Atlas expands the catalog of human non-coding RNAs ', Nature Biotechnology, vol. 39, no. 11, pp. 1453-1465 . https://doi.org/10.1038/s41587-021-00936-1
Nature biotechnology, 39(11), 1453-1465. Nature Publishing Group
ISSN: 1087-0156
DOI: 10.5281/zenodo.5909808
Popis: Existing compendia of non-coding RNA (ncRNA) are incomplete, in part because they are derived almost exclusively from small and polyadenylated RNAs. Here we present a more comprehensive atlas of the human transcriptome, which includes small and polyA RNA as well as total RNA from 300 human tissues and cell lines. We report thousands of previously uncharacterized RNAs, increasing the number of documented ncRNAs by approximately 8%. To infer functional regulation by known and newly characterized ncRNAs, we exploited pre-mRNA abundance estimates from total RNA sequencing, revealing 316 microRNAs and 3,310 long non-coding RNAs with multiple lines of evidence for roles in regulating protein-coding genes and pathways. Our study both refines and expands the current catalog of human ncRNAs and their regulatory interactions. All data, analyses and results are available for download and interrogation in the R2 web portal, serving as a basis for future exploration of RNA biology and function.
Databáze: OpenAIRE
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