HYPOTHALAMIC-PITUITARY-TESTICULAR SYSTEM FOLLOWING TESTICULAR X-IRRADIATION
| Autor: | K. B. Eik-Nes, H. L. Verjans |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
Ventral prostate endocrine system medicine.medical_specialty Hypothalamic pituitary testicular Serum fsh Endocrinology Diabetes and Metabolism Cell Hypothalamus Radioimmunoassay Gonadotropin-Releasing Hormone Gonadotrophin releasing factor Endocrinology Pituitary Gland Anterior Internal medicine Testis Male rats medicine Animals Testosterone Irradiation Serum testosterone business.industry Prostate Seminal Vesicles Organ Size General Medicine Luteinizing Hormone Rats medicine.anatomical_structure Pituitary Gland Follicle Stimulating Hormone Secretory Rate business |
| Zdroj: | Acta Endocrinologica. 83:190-200 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0830190 |
| Popis: | Testes of adult, male rats were exposed to a total dose of 1500 R of X-irradiation. Testicular weight decreased from day 8 after X-ray treatment. This decrease was, however, preceded by an increment of the testis weight on day 4 following treatment. X-ray treatment of testes was associated with significant increases in serum FSH. Testicular irradiation had, however, no effect on ventral prostate and seminal vesicles weights. Serum testosterone increased only on day 1, 2 and 4 after irradiation, while serum LH levels tended to increase from day 8 post-irradiation. These changes were not significant, however, when compared with non-irradiated controls. At 7, 13 and 20 days following 1500 R of bilateral, testicular X-irradiation, the hypothalamic-pituitary unit was still capable of responding to exogenous gonadotrophin releasing factor. Serum FSH may in male rats be regulated at least partly by circulating steroids of testicular origin and partly by an unknown factor of non-interstitial cell nature. |
| Databáze: | OpenAIRE |
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