Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic sudden sensorineural hearing loss from a defined population of Northwest Spain

Autor:	Laura Paco, Juan Carlos Amor-Dorado, Javier Martín, Miguel A. González-Gay, Miguel A. López-Nevot
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Pediatrics Adolescent Hearing Loss Sensorineural Population Human leukocyte antigen Sensitivity and Specificity Age Distribution Reference Values HLA-DQ Antigens Odds Ratio otorhinolaryngologic diseases medicine HLA-DQ beta-Chains Humans Genetic Predisposition to Disease In patient Prospective Studies Typing Sex Distribution education Prospective cohort study Aged Probability Aged 80 and over education.field_of_study Chi-Square Distribution Deafness symptoms business.industry Incidence HLA-DR Antigens General Medicine Hearing Loss Sudden Middle Aged Surgery Phenotype Gene Expression Regulation Otorhinolaryngology Spain Case-Control Studies Sudden sensorineural hearing loss Female Sensory hearing loss business HLA-DRB1 Chains
Zdroj:	Acta Oto-Laryngologica. 125:1277-1282
ISSN:	1651-2251 0001-6489
DOI:	10.1080/00016480510012228
Popis:	The results of this study support the assertion that Southern European individuals have a genetically mediated predisposition to develop idiopathic sudden sensorineural hearing loss (SNHL).To assess the influence of human leukocyte antigen (HLA)-DQB1 and -DRB1 alleles on the susceptibility to and the severity of idiopathic sudden SNHL.A prospective study of patients diagnosed with idiopathic sudden SNHL between October 2000 and September 2002 was conducted. Patients were included in the study if they were diagnosed with idiopathic sudden SNHL within 1 week after the onset of deafness symptoms and had been followed for at least 12 months. HLA-DQB1 and -DRB1 typing was performed from DNA using molecular-based methods on patients and ethnically matched healthy controls.Thirty-three patients fulfilled the inclusion criteria. No significant differences in HLA-DQB1 phenotype frequencies were found between patients and controls (n = 145). Carriage of HLA-DRB1*0403 was significantly increased in the whole group of patients compared with controls (OR = 11.97; 95% CI 1.99-91.60; p = 0.002; p(corr) = 0.04). In patients without auditory improvement the frequency of the HLA-DRB1*04 phenotype was significantly increased compared with healthy controls (OR = 6.57; 95% CI 1.62-26.70; p = 0.003; p(corr) = 0.04).
Databáze:	OpenAIRE
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