Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation
| Autor: | Anne-Christine Peyter, Flavien Delhaes, Steeve Menétrey, Jean-François Tolsa, Giacomo Diaceri |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Pulmonary Circulation Article Subject lcsh:Medicine 030204 cardiovascular system & hematology Nitric Oxide General Biochemistry Genetics and Molecular Biology Muscle hypertrophy Nitric oxide 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Right ventricular hypertrophy Pregnancy Internal medicine Administration Inhalation medicine Animals Humans Adverse effect Hypoxia Cyclic GMP 030304 developmental biology 0303 health sciences General Immunology and Microbiology Inhalation Hypertrophy Right Ventricular business.industry lcsh:R General Medicine Hypoxia (medical) medicine.disease 3. Good health Oxygen Endocrinology chemistry In utero Anesthesia Female medicine.symptom business Research Article Signal Transduction |
| Zdroj: | BioMed Research International, Vol 2014 (2014) Biomed Research International, pp. 949361 BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Adverse events in utero are associated with the occurrence of chronic diseases in adulthood. We previously demonstrated in mice that perinatal hypoxia resulted in altered pulmonary circulation in adulthood, with a decreased endothelium-dependent relaxation of pulmonary arteries, associated with long-term alterations in the nitric oxide (NO)/cyclic GMP pathway. The present study investigated whether inhaled NO (iNO) administered simultaneously to perinatal hypoxia could have potential beneficial effects on the adult pulmonary circulation. Indeed, iNO is the therapy of choice in humans presenting neonatal pulmonary hypertension. Long-term effects of neonatal iNO therapy on adult pulmonary circulation have not yet been investigated. Pregnant mice were placed in hypoxia (13% O2) with simultaneous administration of iNO 5 days before delivery until 5 days after birth. Pups were then raised in normoxia until adulthood. Perinatal iNO administration completely restored acetylcholine-induced relaxation, as well as endothelial nitric oxide synthase protein content, in isolated pulmonary arteries of adult mice born in hypoxia. Right ventricular hypertrophy observed in old mice born in hypoxia compared to controls was also prevented by perinatal iNO treatment. Therefore, simultaneous administration of iNO during perinatal hypoxic exposure seems able to prevent adverse effects of perinatal hypoxia on the adult pulmonary circulation. |
| Databáze: | OpenAIRE |
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