CT imaging of intrathoracic lymph nodes in dogs with bronchoscopically administered iodinated nanoparticles
| Autor: | Patricia E. Losco, Kristen J. Nikula, Gregory L. McIntire, Loren H. Ketai, John L. Toner, Robert D. Rosenberg, Bruce A. Muggenberg, Patrick J. Haley, Bacon Edward R |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Time Factors Contrast enhancement Administration Topical Tracheobronchial lymph nodes Contrast Media Benzoates Dogs Bronchoscopy Parenchyma medicine Animals Radiology Nuclear Medicine and imaging Particle Size Lung Hyperplasia business.industry Macrophages Bronchography medicine.disease Spiral computed tomography Intrathoracic Lymph Node Radiographic Image Enhancement Trachea medicine.anatomical_structure Lymph Nodes Radiology Ct imaging Tomography X-Ray Computed Airway business Iodine |
| Zdroj: | Academic Radiology. 6:49-54 |
| ISSN: | 1076-6332 |
| Popis: | Rationale and Objectives. The purpose of the study was to determine if airway instillation of iodinated nanoparticles results in contrast material enhancement of tracheobronchial lymph nodes in dogs. Materials and Methods. Eight dogs underwent intrabronchial instillation of iodinated nanoparticles; six dogs received 900 mg each, and two dogs received 450 mg each. Spiral computed tomography (CT) was then performed 2–34 days later. Results. CT scans obtained 2 days after instillation showed the presence of contrast material within the lung parenchyma but no nodal enhancement. Scans obtained 6–34 days after instillation showed enhancement of the right, left, and middle tracheobronchial lymph nodes (analogous to the mediastinal nodes in humans). Mean nodal attenuation on CT images was 117 HU ± 43, and the mean nodal volume was 129 mm3 ± 113. Histologic specimens of the nodes showed macrophage hyperplasia. Conclusion. Iodinated nanoparticles instilled into small airways are transported to the tracheobronchial lymph nodes, where they result in contrast enhancement. |
| Databáze: | OpenAIRE |
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