An age-adjusted seroprevalence study of Toxoplasma antibody in a Malaysian ophthalmology unit
| Autor: | Sujaya Singh, Hemah Andiappan, Visvaraja Subrayan, Veeranoot Nissapatorn, Tsung Fei Khang |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Veterinary medicine Adolescent Age adjustment Antibodies Protozoan Logistic regression Odds Immunocompromised Host Young Adult Asian People Risk Factors Seroepidemiologic Studies parasitic diseases Epidemiology Animals Humans Medicine Toxoplasma antibody Seroprevalence Child Aged Aged 80 and over biology business.industry Public health Malaysia Public Health Environmental and Occupational Health Toxoplasma gondii Uveitis Posterior General Medicine Middle Aged biology.organism_classification Ophthalmology Cross-Sectional Studies Logistic Models Infectious Diseases Child Preschool Immunoglobulin G Female Parasitology business Toxoplasma Toxoplasmosis Demography |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 106:322-326 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/j.trstmh.2012.01.009 |
| Popis: | Toxoplasma gondii is a public health risk in developing countries, especially those located in the tropics. Widespread infection may inflict a substantial burden on state resources, as patients can develop severe neurological defects and ocular diseases that result in lifelong loss of economic independence. We tested sera for IgG antibody from 493 eye patients in Malaysia. Overall age-adjusted seroprevalence was estimated to be 25% (95% CI: [21%, 29%]). We found approximately equal age-adjusted seroprevalence in Chinese (31%; 95% CI: [25%, 38%]) and Malays (29%; 95% CI: [21%, 36%]), followed by Indians (19%; 95% CI: [13%, 25%]). A logistic regression of the odds for T. gondii seroprevalence against age, gender, ethnicity and the occurrence of six types of ocular diseases showed that only age and ethnicity were significant predictors. The odds for T. gondii seroprevalence were 2.7 (95% CI for OR: [1.9, 4.0]) times higher for a patient twice as old as the other, with ethnicity held constant. In Malays, we estimated the odds for T. gondii seroprevalence to be 2.9 (95% CI for OR: [1.8, 4.5]) times higher compared to non-Malays, with age held constant. Previous studies of T. gondii seroprevalence in Malaysia did not explicitly adjust for age, rendering comparisons difficult. Our study highlights the need to adopt a more rigorous epidemiological approach in monitoring T. gondii seroprevalence in Malaysia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|