ADAM33 is not associated with asthma in Puerto Rican or Mexican populations
| Autor: | William Rodriguez-Cintron, Ngim Ung, Jose R. Rodriguez-Santana, Edwin K. Silverman, Shweta Choudhry, Pui-Yan Kwok, Dean Sheppard, Moisés Selman, Pedro C. Avila, Natasha E. Coyle, Jean G. Ford, Connie Ha, Keyan Salari, Henry Matallana, Rocio Chapela, Craig M. Lilly, Elad Ziv, Homer A. Boushey, Jorge Salas, Denise L. Lind, Jesus Casal, Elizabeth G. Lovins, Esteban G. Burchard, Sylvette Nazario, Scott T. Weiss, Alfonso Torres |
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| Přispěvatelé: | University of Groningen |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Pulmonary and Respiratory Medicine
Gerontology Proband Male Adolescent Genotype ADAM33 Population Single-nucleotide polymorphism Critical Care and Intensive Care Medicine Polymorphism Single Nucleotide Severity of Illness Index HYPERRESPONSIVENESS Mexican Americans medicine Humans genetics Risk factor education Child Asthma education.field_of_study business.industry Case-control study Metalloendopeptidases Transmission disequilibrium test Hispanic or Latino Immunoglobulin E asthma medicine.disease HISPANICS GENE Bronchodilator Agents respiratory tract diseases Latino populations ADAM Proteins Case-Control Studies TESTS Female business Demography |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine, 168(11), 1312-1316. AMER THORACIC SOC |
| ISSN: | 1073-449X |
| DOI: | 10.1164/rccm.200306-877oc |
| Popis: | A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans. |
| Databáze: | OpenAIRE |
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