Immunohistologic comparison and thrombus NET analysis in stroke and myocardial infarction
| Autor: | Kevin Woollard, Aditya Srivatsan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Neurology 1702 Cognitive Sciences Clinical Neurology Myocardial Infarction 03 medical and health sciences 0302 clinical medicine Immune system Coagulation cascade Internal medicine medicine Humans cardiovascular diseases 030212 general & internal medicine Platelet activation Myocardial infarction Thrombus Stroke Science & Technology Neurology & Neurosurgery Vascular disease business.industry TRAPS Thrombosis 1103 Clinical Sciences medicine.disease PLATELETS cardiovascular system Cardiology Neurology (clinical) Neurosciences & Neurology business 1109 Neurosciences Life Sciences & Biomedicine 030217 neurology & neurosurgery |
| Popis: | Despite extensive characterization of the role of platelet activation and the coagulation cascade in acute ischemic stroke (AIS), few studies have analyzed the immune cell composition of AIS thrombi. Recent articles describing a function of neutrophil-derived extracellular nucleosomes (NETs) in thrombus formation9 highlight the great need for clinical immunohistologic analyses in acute vascular disease. In this issue of Neurology ®, Novotny et al.1 conduct a study comparing thrombus histology between AIS and acute myocardial infarction (AMI), with a focus on the role of immune cells and NETs. |
| Databáze: | OpenAIRE |
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