An Efficient Procedure Based on a MW-Assisted Horner–Wadsworth-Emmons Reaction for the Synthesis of (Z)-3,3-Trisubstituted-a,b-unsaturated Esters

Autor:	Massimo Serra, Anna Caterina Carnevale Baraglia, Simona Collina, Ornella Azzolina, Daniela Rossi
Rok vydání:	2010
Předmět:	Biological Products aryl-alkyl ketones Chemistry Communication Organic Chemistry Horner–Wadsworth–Emmons reaction Pharmaceutical Science Esters Stereoisomerism Alkenes Ketones Horner–Wadsworth-Emmons reaction Organic Chemistry Phenomena (Z)-3 3-trisubstituted α β-unsaturated methyl esters Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Chemistry (miscellaneous) Drug Discovery Rapid access Molecular Medicine Organic chemistry Physical and Theoretical Chemistry microwave-assisted reactions
Zdroj:	Molecules, Vol 15, Iss 9, Pp 5928-5942 (2010) Molecules
ISSN:	1420-3049
DOI:	10.3390/molecules15095928
Popis:	A microwave-assisted HWE olefination process of readily accessible aryl-alkyl ketones has been developed to provide a rapid access to (Z)-3,3-trisubstituted-alpha,beta-unsaturated methyl esters, key building blocks for the synthesis of biologically active compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27e0b832a84881468db0ede742f254e https://doi.org/10.3390/molecules15095928 Zobrazit plný text záznamu Plný text ve formátu PDF