Second-Line Conservative Device-Assisted Intravesical Treatment in Selected Patients With Recurrent High-Risk Non–Muscle-Invasive Bladder Cancer
| Autor: | Marco Racioppi, Luca Di Gianfrancesco, Pierfrancesco Bassi, Emilio Sacco, Giuseppe Palermo, Mauro Ragonese |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Urology medicine.medical_treatment 030232 urology & nephrology Outcomes Cystectomy Device-assisted therapy Group B 03 medical and health sciences symbols.namesake 0302 clinical medicine Second line Humans Medicine Neoplasm Invasiveness Decision making process Fisher's exact test Retrospective Studies Bladder cancer business.industry Settore MED/24 - UROLOGIA Retrospective cohort study Guideline medicine.disease Radical cystectomy Administration Intravesical Treatment Outcome Urinary Bladder Neoplasms Oncology 030220 oncology & carcinogenesis BCG Vaccine symbols Neoplasm Recurrence Local business Non muscle invasive Conservative treatment |
| Popis: | In cases of recurrent high-risk non-muscle-invasive bladder cancer, radical cystectomy (RC) is recommended. We compared oncologic and treatment-related outcomes of second-line conservative device-assisted therapy to RC.In a retrospective cohort study, we analyzed 209 consecutive patients with recurrent bacillus Calmette-Guérin-unresponsive high-risk non-muscle-invasive bladder cancer; 107 subjects refused RC and were offered electromotive drug administration (n = 44) or chemohyperthermia (n = 63) (group A), and 102 patients underwent RC (group B). In group A, patients who did not benefit from device-assisted treatment underwent RC. The endpoints were high-grade disease-free survival, progression-free survival, cancer-specific survival, overall survival, and treatment-related complications. Follow-up was based on international guideline recommendations. Analyses were performed with log-rank and Fisher exact tests.The median follow-up was 59 months (SD ± 5.3). When comparing group A to B, overall survival rates were 91.6% and 90.2%, respectively (P.05); cancer-specific survival was 94.4% and 96.1%, respectively (P.05); high-grade disease-free survival was 43% and 74.5%, respectively (P .05); and progression-free survival was 59.8% and 75.5%, respectively (P .05). Patients with carcinoma-in-situ had worse oncologic outcomes compared to patients with papillary disease. In the multivariate analysis, multifocality, disease recurrence, and progression risk group were independently associated with device treatment failure. The 90-day RC-related overall complications rates were 63.9% in group A and 66.6% in group B (P = .63); grade 3 to 5 complications were 9.8% in group A and 9.8% in group B(P = .99). Complications within group A were comparable (P.05).Device-assisted treatment may a represent a valid second-line conservative tool in selected patients with recurrent high-risk non-muscle-invasive bladder cancer. |
| Databáze: | OpenAIRE |
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