Feasibility of nasal NO screening in healthy newborns
| Autor: | Peter Salfeld, A Aline, Alexander Moeller, Flurina Buechel, Jakob Usemann, Andreas Jung |
|---|---|
| Přispěvatelé: | University of Zurich, Jung, Andreas |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Screening test Niox mino First line 610 Medicine & health Nose Nitric Oxide Gastroenterology Interquartile range Tidal breathing Internal medicine otorhinolaryngologic diseases Medicine Humans 2735 Pediatrics Perinatology and Child Health Primary ciliary dyskinesia business.industry Kartagener Syndrome Infant Newborn Diagnostic test Infant medicine.disease One nostril Breath Tests 10036 Medical Clinic 2740 Pulmonary and Respiratory Medicine Child Preschool Pediatrics Perinatology and Child Health Feasibility Studies business |
| Zdroj: | Pediatric pulmonology. 57(1) |
| ISSN: | 1099-0496 |
| Popis: | BACKGROUND Nasal nitric oxide (nNO) measurement is recommended as a first line screening test for primary ciliary dyskinesia (PCD). While reliable velum- and non-velum-closure techniques exist for preschool children and older individuals, no data are available for neonates. AIMS To determine feasibility of nNO screening and nNO concentration in healthy newborns in the first week of life. METHODS Nasal NO was analyzed in tidal breathing during natural sleep using a CLD-88 sp NO analyzer (chemoluminescence sensor) and a NIOX MINO (electrochemical sensor). Test success and nNO concentration were determined and compared between the two devices. RESULTS Nasal NO was measured in 62 healthy neonates within the first week of life. Feasibility of nNO measurement was 100% for at least one nostril and 85.5% for both nostrils using the chemoluminescence device, but significantly lower with the electrochemical device (85.5% and 53.2%; p |
| Databáze: | OpenAIRE |
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