Polyhydroxylated sterols from Monascus purpureus-fermented rice
| Autor: | Kai-Qi Wang, Xin Wang, Xi-Miao Yang, Xiao-Ya Shang, Jianyu Yue, Xiang-Jian Zhong, Xuan Zhang, Jin-Jie Li, Jiachen Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Clinical Biochemistry
Cell Ethyl acetate Molecular Conformation 030209 endocrinology & metabolism Antineoplastic Agents Hydroxylation Biochemistry 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship 0302 clinical medicine Endocrinology medicine Tumor Cells Cultured Cytotoxic T cell Humans Monascus purpureus Cytotoxicity Molecular Biology Cell Proliferation Pharmacology biology Dose-Response Relationship Drug Organic Chemistry Oryza medicine.disease biology.organism_classification Monascus Sterols medicine.anatomical_structure chemistry A549 Cells 030220 oncology & carcinogenesis Fermentation Adenocarcinoma Drug Screening Assays Antitumor Ovarian cancer |
| Zdroj: | Steroids. 154 |
| ISSN: | 1878-5867 |
| Popis: | Using a cell-based cytotoxicity assay, two new polyhydroxylated sterols, 16(S),22(S)-epoxy-3β,5α,6β,20(R),23(R),25-hexahydroxy-7-ergostene and 3β,7β,8α,25-tetrahydroxy-5,22E-ergostadiene were isolated from the ethyl acetate portion of the ethanolic extract of Monascus purpureus. Their structures were elucidated by spectroscopic analysis and in comparison with those reported in the literature. Both compounds showed cytotoxic activity against the lung adenocarcinoma (A549) with IC50 values of 12.6 and 18.5 μM, exhibited moderate activities against human ovarian cancer (A2780), with IC50 values of 8.8 and 9.4 μM. |
| Databáze: | OpenAIRE |
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