Microwave irradiation of rats at 2.45 GHz activates pinocytotic-like uptake of tracer by capillary endothelial cells of cerebral cortex
| Autor: | Anne M. Phelan, Henry A. Kues, David G. Lange, Cecelia Neubauer |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Endothelium Physiology Central nervous system Biophysics Biology Blood–brain barrier Capillary Permeability chemistry.chemical_compound medicine Colchicine Animals Radiology Nuclear Medicine and imaging Microwaves Cerebrum Pinocytosis Rats Inbred Strains General Medicine Rats medicine.anatomical_structure chemistry Cerebral cortex Permeability (electromagnetism) Blood-Brain Barrier Immunology |
| Zdroj: | Bioelectromagnetics. 11(4) |
| ISSN: | 0197-8462 |
| Popis: | Far-field exposures of male albino rats to 2.45-GHz microwaves (10-microseconds pulses, 100 pps) at a low average power density (10 mW/cm2; SAR approximately 2 W/kg) and short durations (30-120 min) resulted in increased uptakes of tracer through the blood-brain barrier (BBB). The uptake of systemically administered rhodamine-ferritin complex by capillary endothelial cells (CECs) of the cerebral cortex was dependent on power density and on duration of exposure. At 5 mW/cm2, for example, a 15-min exposure had no effect. Near-complete blockade of uptake resulted when rats were treated before exposure to microwaves with a single dose of colchicine, which inhibits microtubular function. A pinocytotic-like mechanism is presumed responsible for the microwave-induced increase in BBB permeability. |
| Databáze: | OpenAIRE |
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