Characterizing the coverage of critical effects relevant in the safety evaluation of food additives by AOPs
| Autor: | Heinz Traussnig, Sara Levorato, Ivonne M.C.M. Rietjens, Siyao Wu, Natalie Thatcher, Mathieu Vinken, Y. Hoffmans, Anette Thiel, Stefan Schulte, Timothy E. H. Allen, Alan R. Boobis, Nynke I. Kramer |
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| Přispěvatelé: | Allen, Timothy [0000-0001-7369-0901], Apollo - University of Cambridge Repository, Liver Connexin and Pannexin Research Group, Pharmaceutical and Pharmacological Sciences, Connexin Signalling Research Group, Experimental in vitro toxicology and dermato-cosmetology |
| Rok vydání: | 2019 |
| Předmět: |
Acceptable daily intake
food.ingredient ADVERSE OUTCOME PATHWAYS Food Safety Novel Foods & Agrochains STRATEGIES BU Toxicologie Health Toxicology and Mutagenesis Novel Foods & Agroketens Toxicology Kidney Risk Assessment Regulatory Toxicology 3Rs food Adverse outcome pathway Environmental health Adverse Outcome Pathway Medicine media_common.cataloged_instance Humans Gastrointestinal irritation BU Toxicology Novel Foods & Agrochains European union Adverse effect Toxicologie media_common VLAG No-Observed-Adverse-Effect Level Science & Technology IDENTIFICATION business.industry Food additive BU Toxicology Data interpretation General Medicine Food additives BU Toxicologie Novel Foods & Agroketens Liver Food Additives 1115 Pharmacology and Pharmaceutical Sciences business Risk assessment Critical adverse effect Life Sciences & Biomedicine |
| Zdroj: | Archives of Toxicology, 93(8), 2115-2125 Archives of Toxicology 93 (2019) 8 |
| ISSN: | 0340-5761 |
| Popis: | There is considerable interest in adverse outcome pathways (AOPs) as a means of organizing biological and toxicological information to assist in data interpretation and method development. While several chemical sectors have shown considerable progress in applying this approach, this has not been the case in the food sector. In the present study, safety evaluation reports of food additives listed in Annex II of Regulation (EC) No 1333/2008 of the European Union were screened to qualitatively and quantitatively characterize toxicity induced in laboratory animals. The resulting database was used to identify the critical adverse effects used for risk assessment and to investigate whether food additives share common AOPs. Analysis of the database revealed that often such scrutiny of AOPs was not possible or necessary. For 69% of the food additives, the report did not document any adverse effects in studies based on which the safety evaluation was performed. For the remaining 31% of the 326 investigated food additives, critical adverse effects and related points of departure for establishing health-based guidance values could be identified. These mainly involved effects on the liver, kidney, cardiovascular system, lymphatic system, central nervous system and reproductive system. AOPs are available for many of these apical endpoints, albeit to different degrees of maturity. For other adverse outcomes pertinent to food additives, including gastrointestinal irritation and corrosion, AOPs are lacking. Efforts should focus on developing AOPs for these particular endpoints. |
| Databáze: | OpenAIRE |
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